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gingivalis -specific antibodies, which are significantly associated with certain autoantibodies and MI risk ( 2.4 Stroke Stroke, a life-threatening cerebrovascular disease characterized by sudden interruption of cerebral perfusion leading to rapid neuronal death, shares overlapping risk factors with periodontitis, including AS, hypertension, and DM ( 2.5 Potential pathophysiological mechanisms Beyond epidemiological correlations, the pathophysiological crosstalk between periodontitis and CVD primarily encompasses two pathways: direct vascular colonization by periodontal pathogens and indirect systemic perturbations triggered by periodontitis-driven inflammatory cascades
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