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This is the pharmacological basis for the once-weekly dosing used in its clinical trials, produces predictable steady-state concentrations at weekly intervals, and means steady state is reached over roughly four to six weeks of weekly administration
Oral hormonal contraceptive effectiveness may be reduced at the start of treatment and after dose increases consider a non-oral backup contraceptive method for 4 weeks after initiation and after each dose escalation
Group 2 was a vehicle control that received local Hydrogel and an intravenous injection of saline
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