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A 2025 comprehensive review in Medical Science Monitor covering studies from 20162025 confirmed that GHK-Cu-based formulations enhance fibroblast migration, ECM remodelling, collagen and elastin synthesis, and wound closure across multiple model types

Fifty of the 173 users discontinued the agents before the 1-year study period was up, most often for gastrointestinal symptoms and "insurance issues." Limitations to the study included its single-center, retrospective design and small sample size

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