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Dapagliflozin was negative for clastogenicity in a series of in vivo studies evaluating micronuclei or DNA repair in rats at exposure multiples greater than 2100times the clinical dose

Statistical Analysis and Sample Size Statistical analysis was performed using GraphPad Prism Software 8 using one-way ANOVA for comparing more than two categories with Tukey corrections

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Propensity score matching incorporated demographics, comorbidities, ocular history and medications