Dipeptidyl peptidase 4 inhibition stimulates distal tubular natriuresis and increases in circulating sdf-1alpha(1-67) in patients with type 2 diabetes
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Both experimental and clinical studies have reported iron accumulation, enhanced lipid peroxidation, and reduced glutathione peroxidase 4 ( GPX4 ) expression in DKD kidney tissue, supporting ferroptosis as a potential mechanistic link between tubular injury, oxidative stress, and renal fibrosis (Wu and Chen, 2022)