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Hediger, Matthias

In this sense, the use of TNF- inhibitors has been linked to an amelioration of self-esteem, wellbeing, sensory functions and alteration of brain responses in left amygdala, right prefrontal cortex, posterior cingulate cortex and primary visual regions, demonstrating modifications in cognitive-affective processing ( In this regard, research also demonstrates that the use of anti-TNF- drugs presents superior impacts in depressive scenarios when compared to other immunomodulators (Horst et al., 2015)

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This in turn leads to the induction of AP-1-dependent target genes, involved in cell proliferation, DNA repair, and cell death 27