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Notably, NO and its derivatives (e.g., nitrite and nitrate) are more stable and less susceptible to rapid degradation under the antioxidant systems of serum 37 .The enzymatic antioxidants, including GPX, CAT, SOD and thioredoxin reductase (TrxR), play key roles in mitigating oxidative stress induced by ROS and free radicals 38
OC is the 5th most common malignancy in women and the leading cause of death from gynecologic malignancies (6)
Coskun Mol Metab 2018
748 Inhibition of this pathway using the PAR1 antagonist vorapaxar has been shown to reduce the burden of senescent cells, offering a potential therapeutic strategy
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