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The most common dose for treating deficiency is 1,000 mcg
Once administered, hydroxocobalamin undergoes conversion in the body to active forms of B12, such as methylcobalamin and adenosylcobalamin
?, Human = ~0.069 nM) and greater resistance to enzymatic degradation by DPP-IV 2,3
In fact, one study found that peoples bodies absorbed about 49% of a 1-mcg dose of cyanocobalamin, compared to 44% of the same dose of methylcobalamin ( Conversely, another study comparing the two forms reported that about three times as much cyanocobalamin was excreted through urine, indicating that methylcobalamin may be retained better within your body ( However, some research suggests that differences in bioavailability between the two forms may be insignificant and that absorption could be influenced by factors such as age and genetics ( Unfortunately, recent research directly comparing these two forms of vitamin B12 is limited
