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Historically, the brain has been considered an immune-privileged organ that is shielded from peripheral immune interactions by the bloodbrain barrier (BBB) [6]

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The body is generally really effective at detoxifying itself

What stood out was that these benefits: Appeared across a wide range of body sizes Were only partly explained by weight loss And persisted even when changes in body fat were modest Follow-up analyses confirmed that improvements in cardiovascular outcomes could not be fully attributed to changes in body weight or waist circumference alone