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From short-acting to long-acting formulations, the wide range of GLP- 1 receptor agonists available provides physicians with numerous options to tailor treatment to each patient's needs

PMC 4456003

Semaglutide, a selective GLP-1 receptor agonist, primarily acts on central appetite regulation and gastric emptying, leading to reduced caloric intake, improved satiety, and clinically meaningful reductions in glycated hemoglobin (1.31.6%) and body weight

Biological actions of GLP-1, source: reference [1] Biopharma PEG Evolution of GLP 1 GLP-1RAs Currently, there are nine GLP-1RAs approved for marketing worldwide (Table 1), mainly for the treatment of diabetes and obesity, of which tirzepatide is a novel dual GLP-1RA/GIPR agonist