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STEP UP: In adults with obesity, along with diet and exercise, Wegovy HD (semaglutide) injection 7.2 mg: Designed to deliver greater weight-loss results than the Wegovy you know 1 Mean change in body weight (%) from week 0 to week 72 1 Co-primary end point 1 : Percentage of patients achieving 5% weight loss at 72 weeks: 88.7% of patients with Wegovy vs 38.3% with placebo HD Treatment regimen estimand: This estimand is based on the intention-to-treat principle and was used as the primary analysis method *Co-primary end point: % change in body weight for Wegovy HD vs placebo

Translation to human clinical application has been narrower than the breadth of the preclinical literature for any of the three components

Going too long without eating and skipping meals can easily lead to catch-up hunger as the day goes on or even creating more hunger into the next day

GLP-1s and Hypogonadism A small study found that GLP-1s administered to overweight or obese men with diabetes improved testicular function, primarily through weight reduction and by rebalancing the suppression of the HPG axis caused by obesity