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In the SURMOUNT-1 trial, patients lost an average of 22.5% of body weight over 72 weeks

They may recommend a dose reduction, a longer time between escalations, or a switch to a different GLP-1 compound like tirzepatide, which activates both GLP-1 and GIP receptors and may have a different side-effect profile for your specific metabolism

Treatment with 500 ng/mL PTX reversed the inhibition of pasireotide on GLP-1 secretion and cAMP accumulation (Fig