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GLP-1 receptor agonists in diabetes for stroke prevention: a systematic review and meta-analysis

In a retrospective analysis of adults with a BMI of 40 kg/m 2 or higher who were prescribed once-weekly semaglutide 2.4 mg (Wegovy, Novo Nordisk), those who previously underwent bariatric surgery and did not lose a sufficient amount of weight or regained weight after the procedure lost 9.8% of their body weight at 24 weeks and achieved an excess weight loss of 23.2%

The way a program handles dose increases, side effects, and follow-up support can shape how manageable treatment feels over time

Am J Physiol 290(4):G747G756 Shimomura Y, Harada M, Goto M, Sugo T, Matsumoto Y, Abe M et al (2002) Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8