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Surface characteristics such as charge, hydrophobicity, and functionalization with polymers or targeting ligands can modulate protein adsorption patterns, thereby affecting the biological identity of nanoparticles in vivo ( Cross-linking agents such as carbodiimide promote the covalent attachment of ligands to particle surfaces, enhancing their biocompatibility and efficacy in associating nanoparticles with specific ligands

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C., Mazumder, K., Bachar, R., Aktar, A