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Participants taking the highest dose also lost an average of 16 pounds

The FDA approved this drug for use in weight management in Research from 2023 has found that people taking Wegovy lost more weight than those taking a placebo, with a mean difference in total weight loss of Zepbound Zepbound received FDA approval for use in weight management in Saxenda Saxenda received While Saxenda is effective for weight loss, people may notice slower or less obvious results

Also, during STEP 5, a study to assess efficacy of semaglutide with a follow-up of 2 years, there is a post-hoc analysis that demonstrates a better performance in the self-reported Control of Eating Questionnaire(CoEQ) to measure changes in appetite versus placebo, with lower cravings for dairy and starchy foods and less desire for salty and spicy food at short-term (20 weeks) but also as a maintenance therapy at weeks 52 and 104 (178)

However, initial studies of tesofensine for these neurological conditions wasn't successful