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Why the comparison matters Here is why this matters practically

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[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Aldini G., Altomare A., Baron G., Vistoli G., Carini M., Borsani L., Sergio F

Mass Spectrometry Applications Mass spectrometry enables: N-terminal truncation identification C-terminal truncation analysis Relative impurity quantification Structural confirmation of shortened variants Why Truncation Monitoring Matters These variants can potentially affect: Product potency Stability Pharmacokinetics Regulatory comparability assessments As a result, truncation products must be carefully monitored throughout biosimilar development