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Because these medications dont need to be injected as deeply, they typically use a much shorter and thinner needle than intramuscular injections

Incretin mimetics generally produce greater reductions in HbA1c, typically lowering levels by 1.01.5% (1116 mmol/mol), compared to DPP-4 inhibitors, which achieve more modest reductions of 0.50.8% (59 mmol/mol)

Individual variation is significantsome patients feel nearly symptom-free by day 10, while others require 6 to 8 weeks for complete resolution

However, a major challenge in introducing GLP-1 as a novel therapy for type 2 diabetes is its rapid inactivation by DPP-4 (75)