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Insulin Resistance (If Misused Long-Term) Paradoxically, while IGF-1 LR3 can improve insulin sensitivity when used properly, chronic overuse may lead to receptor desensitization and eventual insulin resistance especially when paired with poor diet

Diabetes medications: GH peptides and MK-677 can reduce insulin sensitivity

The growth hormone and IGF-1 it triggers continue working in the body well beyond that window, which is why once-daily dosing is effective despite the short half-life

It has been reported that IGFBPs can bind approximately 98% of all circulating IGF-1, and their binding affinity for IGF-1 is nearly 10 times higher than that for IGF-1R (Zhong et al., 2023)