glp 1 agonists for type 2 diabetes GLP-1-based therapies diabetes: from single, dual and triple to endogenous GLP-1 production and L-cell differentiation | Diabetology & Metabolic Syndrome Evolution of GLP‐1 Receptor Agonists

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Glucagon is also involved in acutely regulating glucose homeostasis and administration of pharmacological doses of glucagon in animal models for diabetes or obesity has demonstrated regulatory effects on lipid metabolism, energy expenditure, and food intake (41, 50)

Table 33 Number of sub-visible particles in histidine-buffered cagrilintide and semaglutide co-formulations containing HP-B-CD of varying hydroxypropyl molar substitution degree Results for number of sub-visible particles are the mean of 3 replicates and have been rounded to nearest integer value 1 MS: molar substitution, corresponds to hydroxypropyls per glucose unit Concluding Remarks The results presented in table 33 show that the histidine-buffered co-formulations 33-37, comprising HP-B-CD with a wide range of molar substitutions (Average MS: 0.62- 0.92), remained physically stable for 28 days

Availability of data and materials All data generated or analyzed during this study are available from the corresponding author upon reasonable request