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Abstract Alcoholic liver disease (ALD) is a global health concern caused by chronic excessive alcohol consumption, and dietary intervention is a key strategy for improving ALD

Orlistat works by blocking fat absorption in the gut and carries a documented risk of kidney stones and oxalate nephropathy, making it generally unsuitable for people with CKD or a history of kidney stones

At such high levels of drinking, the biology behind cravings and consumption could be completely different and I think it's entirely possible the drugs won't pack the same punch once you get into that extreme territory