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We approached this by identifying omics- features (i.e., expression, mutation, copy number, pathways, metabolites, etc.) that are predictive of NRF2 CRISPR knockout scores from the DepMap

250 of PBS containing human HGF (1.25ng) were incubated with 3 H-Hinge, the central dimerization domain of HGF, in the presence of varying concentrations of 6-AH analogs between 10 ~ ' 3 M to 10 "7 M (half-log dilutions) for 40 min at 37C

Heterogeneity was non-significant in all other meta-analyses, except for ACC glutamate (k = 3) and cortical GABA (k = 3), in which instances no clear cause was evident

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