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OECD expert group recommendations are to include some active metabolites where possible (159, 236, 237)

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Session Information Date: Thursday, June 8, 2017 Session Title: Clinical Trials and Therapy in Movement Disorders Session Time: 1:15pm-2:45pm Location: Exhibit Hall C Objective : To study the impact of MitoQ and GSH against DA induced rat brain mitochondrial electron transport chain inhibition during extended in vitro incubation

The hexobarbital test could serve as a useful tool for these investigations