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10.1038/s41598-018-26296-6 86 RibasV.Garca-RuizC.Fernndez-ChecaJ

Both original research articles and reviews were considered

The gradual death of neurons, resulting in a loss of brain function, such as cognition, age-related dysregulation of biochemical pathways, and alterations of gene expression, is poorly understood and current therapies are still ineffective