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Zepbound and WeGovy, for example, are approved for weight management in adults who have obesity or are overweight with at least one weight-related condition, such as high blood pressure or Type 2 diabetes

Currently, both peptides are approved for MACE reduction based on the following data: The effectiveness of semaglutide for reducing MACE risk was studied in the SUSTAIN-6 trial, which included a total of 3297 diabetics, the majority of which had cardiovascular risks

Given the narrative design of this review, inclusion was based on conceptual and mechanistic relevance rather than rigid methodological scoring or quantitative pooling