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Clinical relevance of all these findings can be appreciated by studies showing association of hepatic DNA damage, increased expression of cell cycle inhibitors such as p21, and cell cycle arrest with impaired liver regeneration response in APAP-induced ALF patients [23,35]

Encapsulation efficiency was measured using ICP-MS and revealed excellent encapsulation efficiency of DDA-GSH-AuNCs into PLGA matrix (93.09 1.71%), owing to the hydrophobic character of the nanoclusters that prevents its partition into the external polar phase (ethanol) and rather get encapsulated in the hydrophobic PLGA matrix

Consistently, the present study revealed that GSSSG could attenuate LPS-induced increase of proinflammatory cytokines at the mRNA and protein levels in glial cells, including Mller cells and microglia, which are key players responsible for regulation of the inflammatory state in the retina under pathological conditions 42,44

10.1016/j.jns.2020.117253 26 BhattS.PuliL.PatilC