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By January 1963 Nordin had made enough progress to present to what Jerne described as 'a plate with hundreds of tiny plaques that, after staining the red cell background with benzidine, looked like stars in a cloudless sky.' Sent the following month to Science Jerne says 'The importance of being able to count the number of cells secreting a specific antibody was immediately clear to everybody to whom we showed these pictures' (Jerne, 1981)

Finally, restrain-free production run was carried out for each simulation, with a time step of 2 fs in the NPT ensemble at 310 K and 1 bar using the Nose-Hoover thermostat and the semi-isotropic Parrinello-Rahman barostat 61 , respectively

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We modified GEP44 at its N-terminus to generate GEP12