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Overall, HT pathogenesis results from a complex interplay between innate and adaptive immunity, where breakdowns in tolerance, skewed Th1/Th17/Treg balance, and persistent autoantibody production sustain chronic inflammation and irreversible thyroid destruction

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Evolutionary medicine complements traditional science-based medicine, and is an approach that highlights humankinds slow adaptation to a rapidly changing environment, and which examines our continuing susceptibility to disease within the context of continuing evolution