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The September 2023 label update acknowledging ileus risk came only after the FDAs own adverse event reporting system documented numerous cases, raising questions about why this warning wasnt included from the drugs initial approval

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Como punto de partida, la Alianza Internacional de Asociaciones de Suplementos Alimentarios (IADSA, en sus siglas inglesas) present en 2007 un informe en el que cita los estudios cientficos que se han realizado para determinar las dosis de seguridad de nutrientes como glucosalina, omega-3, creatina, coenzima Q-10, condroitina, carnitina, lutena y licopeno

However, incidence of developing NAION is still very low: in one study, only 0.2% of all studied patients developed NAION