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A phase 2 trial (NCT03061721, EVIDENCES IV) was completed in 106 MASH patients, resulting in amelioration of ALT levels, hepatic steatosis, dyslipidemia, and insulin resistance
At the same time, a significant loss of mucus-producing goblet cells was found, pointing towards impairment of intestinal barrier function and homeostasis
Although you cannot completely prevent loose skin and sagging during rapid weight loss, some strategies that may help are losing weight gradually under medical supervision, staying well-hydrated, and maintaining a nutrient-rich diet to support skin health
Terada N, Karim MR, Izawa T et al (2017) Immunolocalization of -catenin, E-cadherin and N-cadherin in neonate and adult rat kidney
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