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The preclinical literature is extensive and spans more than three decades, with animal model data generally supporting a manageable safety profile at the concentrations and study durations examined

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doi: 10.1210/jcem.87.4.8414 127 De Lind van WijngaardenRFASiemensmaEPCFestenDAMOttenBJvan MilEGAHRotteveelJet al

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