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A study evaluating the effectiveness of a 45-day VLEKT in improving acne in 31 young women with moderate acne and grade I obesity showed a reduction in markers of oxidative stress, such as reactive oxygen metabolite derivatives (dROMs), and a decrease in pro-inflammatory metabolites, including trimethylamine N-oxide (TMAO)

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Furthermore, the neurotransmission decrease conducts to an excess of neuroinhibition, which contributes to encephalopathy

Notably, the 65% reduction in hs-CRP levels observed in one study was statistically significant, independent of body fat mass and body weight [48]