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Variations, especially in foods of plant origin, could be attributed to factors such as plant varieties and cultivars, growing conditions (e.g., season and climate), and agronomic practices (e.g., harvest time and postharvest handling)

For the primary composite endpoint of myocardial infarction, stroke or all-cause mortality, benchmarking identified high agreement between the reference trials and their emulations for all individual endpoints except for all-cause mortality in SUSTAIN-6, informing subsequent analyses