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Hunger can sneak up fast and feel awful when it does

Consequently, people using GLP-1 medications for weight loss may litigate more readily over unanticipated or adverse side effects

The widely used human in vitro model is the THP-1 cell line, which is derived from leukemic monocytes and can be differentiated into macrophages

Given cryo-EM structures of the GLP-1R in complex with G s are stabilised by trapping the nucleotide-free G protein on the ligand-activated receptor, it is not surprising that the G s interactions are similar across the four structures, even when bound by different agonists, nonetheless, the MD simulations revealed potential differences in the dynamics of these interactions