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The paper suggests initiating therapy at roughly 1025% of standard starting dose for type 2 diabetes or obesity, which for tirzepatide (approved starting dose 2.5 mg) would be roughly 250625 g, or 0.25 0.625 mg

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Randomized, double-blind, placebo-controlled trial of oral docusate in the management of constipation in hospice patients

Spermidine delays aging through multiple pathways, such as the activation of autophagy, the regulation of epigenetic modifications, the improvement of mitochondrial function and the inhibition of inflammation, and has shown potential for improving healthspan in model organisms (yeasts, Drosophila , nematodes, and mice) 429 and humans