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Furthermore, development of small molecule agonists or antagonists is often performed via binding a certain and definite site in the target molecule while PROTAC is not dependent on these certain sites as it is implemented via the efficient building of a ternary complex between the PROTAC molecule, the protein of interest and the E3 ligase

The Colbert Report, Episode 1017 Archived September 27, 2007, at the Wayback Machine "Elijah Wood and Stephen Colbert Compare 'LOTR' Sting Swords (VIDEO)"

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