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As part of the AngioSafe 1 study, both an observational and interventional phase IV study of patients with T2D showed that GLP-1R agonists did not increase the risk for severe diabetic retinopathy ( thiazolidinedione and long-acting insulin where GLP-1R agonists did not increase the risk of diabetic retinopathy over an average treatment time of less than 1 year (Wang et al., 2018)

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