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doi: 10.1021/acsami.4c05989 115 ZhouL-LGuanQDongY-B

To facilitate meaningful comparison with the healthy comparison group and quantify effect sizes, brain outcome measures were normalized to z scores using the mean and SDs from the healthy control groups in both cross-sectional and longitudinal clinical studies

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There have been multiple criminal charges levied against the founders, including distributing unapproved drugs after a warehouse raid from the FDA, but all charges were dropped by 1996.15 Then, in 2017, Life Extension was issued a warning for claiming that its products could cure diseases such as breast cancer.16 Because the FDA doesn't regulate supplements, its illegal for companies like Life Extension to claim that supplements will treat, diagnose, prevent, or cure diseases.17 Most recently, in April 2023, Life Extension was named as a recipient of the FTCs Notice of Penalty Offenses Concerning Substantiation of Product Claims