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GLP-1 therapy can improve insulin sensitivity directly and indirectly through weight loss, better glucose control, and reduced visceral fat

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Patients Starting GLP-1 Therapy Some doctors prescribe oral semaglutide as a test run for patients who: Want to assess GLP-1 tolerability before committing to injections Have concerns about nausea and want to try a lower-exposure option first Plan to transition to injections after demonstrating good tolerance This strategy can build confidence, though starting directly with injectable therapy (at the lowest dose) often works just as well