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Interference of the p53-FOXO4 interaction resulted in selective apoptosis of senescent cells and restoration of tissue homeostasis in multiple mouse models

Clinical data were retrieved from the electronic medical records, and morphologic features, maximal mitotic counts, Ki67 labeling indices, and immunohistochemical profiles (SOX10, SOX2, p75NTR, p16, p53, EGFR, and neurofibromin) were assessed

We monitor not just weight loss but improvements in metabolic markers, energy levels, and quality of life measures throughout treatment

Currently, the long-acting GLP-1 analogues exenatide and liraglutide are being investigated as potential anti-obesity drugs, with early indications that this may indeed be worthwhile