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Associated conditions: Code separately any associated extraintestinal manifestations (arthropathy, uveitis, erythema nodosum, PSC) when documented by the provider as related to Crohns disease

Essex MJ, Shirtcliff EA, Burk LR, Ruttle PL, Klein MH, Slattery MJ, et al

95% CI, 0.27-0.92)

7 Changes in the brain cytoplasmic [NAD + ]/[NADH] and [NADPH]/[NADP + ] with aging are rodent strain and species specific Through measuring the metabolome of young and aged C57BL/6J mouse brains, the lactate/pyruvate, a proxy for the cytoplasmic [NADH]/[NAD + ], was found to increase by 34%52% with aging, indicating a cytoplasmic reductive shift (Dong and Brewer, 2019), opposite to the oxidation of mitochondrial [NADH] that was found to occur in aged neurons (Dong et al., 2019a)