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Therefore, by introducing the DRP1-specific inhibitor mdivi-1, we observed that DRP1 inhibition significantly synergized with KU-57788 to suppress ATC cell viability and colony formation (Fig
Treatment of iatrogenic hypothyroidism is to reduce methimazole/carbimazole dose, if the cat is receiving it, or supplement with levothyroxine (10g/kg/day to 20g/kg/day), which can be adjusted to maintain normal T 4 and TSH
Collectively, these findings indicate that reduced adipocyte mitochondrial CI activity during obesity is a key driver of visceral WAT metabolic dysfunction and subsequent systemic impairment in metabolic health
Acknowledgements This work was partly supported by joint funding from the Japan Diabetes Foundation and Novo Nordisk Pharma, Ltd
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