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5 The proposed mechanisms are coherent and biologically plausible

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In contrast to glutamate, whose level is independent of the mood of depressed subjects, the GABA level is state dependent, as its concentration in remitted MDD subjects is similar to healthy controls ( 1 H-MRS studies in MDD subjects have shown restoration of GABA level after electroconvulsive therapy (98), cognitive behavioral therapy (74), treatment with ketamine (150), and selective serotonin reuptake inhibitors (SSRIs) (97)