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Step-by-Step Mechanism of Action GLP-1 Receptor Activation GLP-1 receptor agonists bind to and activate the GLP-1 receptors, which are G-protein-coupled receptors located in pancreatic beta cells, the brain, gastrointestinal tract, and heart

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However, most studies are based on the analysis of stool microbiota which may not be fully representative of the small intestinal microbiota which can translocate through the intestinal barrier