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Initial concerns were raised after findings from the cardiovascular outcome trial (CVOT), Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes 6 (SUSTAIN 6), revealed a greater risk of DR-related complications, defined as the need for laser therapy, intravitreal injections, development of vitreous hemorrhage, and blindness, in semaglutide users compared to placebo (3.0% vs 1.8%, HR=1.76, P =.02)

offered an improved perspective for the long-term cost-effectiveness of GLP-1 RAs by showcasing benefits in QALYs and reduced lifetime healthcare costs [81]

This oxidative damage can promote the release of autoantigens and disrupt immune tolerance, contributing to the initiation of autoimmune responses against the thyroid