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The result is that GI effects that were prominent in week one diminish by week four, even though drug levels are actually higher by week four than week one

Among xenobiotics metabolized by CYP2E1 are acetaldehyde, acetaminophen, acrylamide, aniline, benzene, butanol, carbon tetrachloride, diethylether, dimethyl sulfoxide, ethyl carbamate, ethylene chloride, halothane, glycerol, ethylene glycol, N -nitrosodimethylamine, 4-nitrophenol, pyrazole, pyridine, and vinyl chloride

Though the mechanism(s) underlying the decreased risk of incident and recurrent CUD with semaglutide is unclear, several mechanisms could be involved

10.3389/fcell.2021.778011 209 ZhangY.LiuM.ZhangY.TianM.ChenP.LanY.et al (2022c)