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In severe cases, prolonged B vitamin deficiency can lead to beriberi, pellagra, or Wernicke-Korsakoff syndrome, the last of which causes serious neurological problems

13 C-glutamine and cystine labelling experiments Cells (5 10 5 ) were plated onto six-well plates and cultured in standard medium for 12 h

This, in combination with several structural changes directed at the N-terminal end of the peptide, including the substitution of d-norleucine for l-norleucine, the N-acetylation of norleucine, and the replacement of norleucine with the non--amino acid -aminobutyric acid (GABA) results in reduced susceptibility to aminopeptidases and overall improved bioavailability of Dihexa

These include nausea, diarrhea, and vomiting