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Guanylate Cyclase-C Agonists Examples: Linaclotide, Plecanatide Mechanism: cGMP activates CFTR channels intestinal fluid secretion accelerate transit Uses: Chronic constipation, IBS-C Adverse Effects: Diarrhea, abdominal pain Bulk-forming safest, long-term use Osmotic acute or hepatic encephalopathy (lactulose) Stimulants short-term only Stool softeners post-surgery, hemorrhoids Lubricants avoid long-term Chloride channel activators & GC-C agonists newer agents for chronic constipation Mnemonic for Laxatives: BOSS-LC B Bulk-forming O Osmotic S Stimulant S Stool softeners L Lubricant C Chloride channel activators / cGMP agonists To view or add a comment, sign in More Relevant Posts Common medications cause nutrient deficiencies (and what to monitor) Many widely used drugs can reduce absorption or increase urinary losses of key vitamins/mineralsespecially with chronic use, higher doses, older age, limited intake, GI disease, or after bariatric surgery

Sterile water lacks the benzyl alcohol preservative found in bacteriostatic water, which prevents bacterial growth in multi-dose vials stored in refrigeration

The procedure involves a tool that cuts these tethering bands under the skin

What happened to compounded semaglutide availability