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confirmed the enhanced percentage of eryptosis in HD patients and reported a positive correlation between the percentage of circulating eryptotic cells and ROS and ceramide concentrations, and between the percentage of PS-exposing erythrocytes and both erythropoietin dosage and the percentage of reticulocytes [265]

Glutamine has historically been one of the most intensely investigated nutrients in cancer metabolism and is involved in various aspects of biosynthesis and bioenergetics, including NEAA production, epigenetic gene control, adaptation to hypoxic conditions, ATP synthesis, cell signaling, and tumorigenesis

These findings present erythrocytes as adaptable, multifunctional cells that connect cellular metabolism, vascular biology, and translational research