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[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Gonzalez M.L., Chernock R.D., Mansour M

Even with an active nomination, injectable GHK-Cu would face a tougher path through PCAC because the safety bar for an injectable is higher than for a cream

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Physical enhancement methods including iontophoresis, microneedling, and ultrasound also significantly increase GHK-Cu delivery, with microneedling pre-treatment increasing peptide penetration by approximately 10-fold compared to intact skin application, effects similar to those achieved with other topical peptide formulations optimized for transdermal delivery