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In an additional analysis using the KC mouse model, GLP-1 treatment was administered to animals with cerulein-induced pancreatitis
Together, this double activation may produce more consistent effects on motivation, regulating energy balance and reward simultaneously, and possibly amplifying anti-craving effects
According to NICE guidance (NG28), GLP-1 agonists are recommended for type 2 diabetes in specific circumstances, typically as third-line therapy when other treatments haven't achieved adequate glycaemic control, and in people with a BMI 30 kg/m (adjusted for ethnicity)
Key lipid changes with GLP-1 receptor agonists include: Triglycerides: 15-25% reduction Total cholesterol: 3-8% reduction LDL cholesterol: 3-7% reduction HDL cholesterol: 2-5% increase Non-HDL cholesterol: 5-10% reduction The SELECT cardiovascular outcomes trial demonstrated that semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% in patients with established cardiovascular disease who were receiving standard background care
